Investigation of the differential expression of gasdermins and ninjurin 1, which are responsible for pyroptotic cell death and plasma membrane rupture, and of potential mechanisms in ovarian cancer, using clinical samples and ovarian cancer cell lines. Supported by The Scientific and Technological Research Institution of Turkey (TUBITAK-1001).
Determination of the effects of one-carbon metabolism supported by serine/glycine amino acids and SHMT/GLDC enzymes on cancer proliferation, migration and chemo-resistance in cisplatin-resistant ovarian cancer cells . Supported by The Health Institutes of Turkey (TUSEB).
The Investigation of the Effects of Immunotherapy-Focused IDO1 and BIRC5 Inhibition on Immune Checkpoint Mediators in Pancreatic Cancer. Supported by The Health Institutes of Turkey (TUSEB).
Attenuation of the IL-6-mediated epithelial-mesenchymal transition (EMT) process in colorectal cancer cells by using the combination of tocilizumab and bortezomib and determining its effect on immune checkpoint modulators such as PD-L1 and CD80. Supported by The Health Institutes of Turkey (TUSEB).
Investigation of the epigenetic and transcriptional regulation of Immune Checkpoints in Pancreatic cancer and their potential roles in Epithelial-Mesenchymal Transition. Supported by The Scientific and Technological Research Institution of Turkey (TUBITAK-1002).
Determination of the post-effects of Sars-Cov-2 infection on Epithelial-Mesenchymal Transition. Supported by The Scientific and Technological Research Institution of Turkey (TUBITAK-1002).
Investigation of the potential effects of mitotranscriptome on the development of chemoresistance in ovarian cancer. Supported by TÜBİTAK Directorate of Science Fellowships and Grant Programme (BIDEB-2218).
Investigation of the Effects of Bioactive Molecules Derived from Intestinal Symbiotic Bacteria on Anoikis Resistance in the Scope of Colorectal Cancer Metastasis. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Investigation of Regulation of LKB1 and STING Genes in Gynecological Cancers. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Determination of the Prevalence of Hepatitis E Virus in Neurological Diseases and Genetic Investigation of Its Effect on the Innate Immune Responses. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Increasing Immunogenic Cell Death in Colorectal Cancer by Using Low-Dose Bortezomib and Epirubicin Combination. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Investigation of estrogen-dependent and epigenetic regulation of GSDMC and GSDMD in colorectal cancer. Supported by The Scientific and Technological Research Institution of Turkey (TÜBİTAK-2209).
Regulation of STING in Endometrial Cancer. Supported by The Scientific and Technological Research Institution of Turkey (TÜBİTAK-2209).
Investigation of the Effect of Proteasome and PARP-1 Inhibition on Chemoresistance and Chemosensitive Ovarian Cancer Cells. Supported by The Scientific and Technological Research Institution of Turkey (TÜBİTAK-2209).
Investigation of the correlation between DYNLL1 expression levels and chemoresistance in different ovarian cancer. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Investigation of the correlation between NKG2D gene expression levels and immunogenic cell death in colorectal cancer. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Investigation of epigenetic regulation of DYNLL1 in ovarian cancer. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Investigation of the Effect of Palbosislib in Chemoresistance Ovarian Cancer Cells, Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Investigation of the Effect of Proteasome Inhibition on Death Receptors in Breast Cancer. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Effects of Some Agents Used in the Treatment of Obesity on Colorectal Cancer and Determination of Potential Epigenetic Regulations of Target Genes. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Increasing Cisplatin Sensitivity of Chemoresistance Ovarian Cancer Cells, Supported by The Scientific and Technological Research Institution of Turkey (TÜBİTAK-2209)
Investigatıon the roles Toll-Like Receptors in Drug Resistance in Ovarian Cancer. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Investigation the roles of chemoresistance-associated protein DYNLL1 in ovarian cancer. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Collaborating Projects
Novel Diaryl Urea Synthesis as a p38-MAPK Inhibitor: Gastric Cancer Drug Design. Supported by The Scientific and Technological Research Institution of Turkey (TÜBİTAK-1001).
Synthesis and characterization of new generation molecules containing gold and platinum. Supported by The Scientific and Technological Research Institution of Turkey (TÜBİTAK-1001).
Determination of expression levels of some genes involved in DNA repair mechanism in lip cancers and their relationship with tumor development. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Investigation of CD44/CD90 cell surface proteins in terms of MAP Kinase and apoptotic signaling pathways in patients with chronic venous insufficiency.Compounds. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP).
New AZA-Bodipy Molecules and Determination of Photoactivity of These Compounds. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Preparation, Characterization and Determination of Biological Activity of New Amino Acid Schiff Bases and Copper II Complexes. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Determination of ROS activity levels and cell cycle and apoptosis-related protein expression in tumor and normal tissues obtained from colorectal tumor-formed wistar albino rats. Supported by Siirt University, Scientific Research Project Unit (BAP)
Investigation of ER Stress Response in Gingival Tissue in Patients with Diabetes and Periodontitis. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Production of rosmarinic acid with bioreactor systems in adventitious root culture of Ocimum basillicum L. and investigation of the expression of biosynthesis genes. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Production of graft material containing demineralized freeze-dried cementum/dentin and evaluation of its applicability as a graft material. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Investigation of cytotoxic and apoptotic effects of melatonin, cisplatin and cannabis cannabinoids (Cannabidiol Tetrahydrocannabinol) on human lung cancer cell lines. Supported by Yozgat Bozok University, Scientific Research Project Unit (BAP)
Investigation of Hypoxia-Induced Factor (HIF) Signaling Pathway Associated with Daily Cigarette Smoking in Periodontally Healthy Individuals. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Synthesis and characterization of new generation aza-BODIPY molecules. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Determination of the roles of different apoptosis and inflammation pathways in aggressive periodontitis disease. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Regulation of the NLRP13 and RGS10 genes in Familial Mediterranean Fever Patients and evaluation of the relationship between disease and the proteins involved in proptosis. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)
Investigation of the potential roles of some genes to induce the formation of inflammation and epigenetic regulation in these genes in FMF patients in remission and attack period. Supported by Tokat Gaziosmanpasa University, Scientific Research Project Unit (BAP)